Just like other μ-opioid agonists, tapentadol might trigger spasms with the sphincter of Oddi, and is particularly thus discouraged to be used in individuals with biliary tract disease including equally acute and Continual pancreatitis. People who are fast or extremely rapid metabolizers with the CYP2C9, CYP2C19, and CYP2D6 enzymes might not respo… Read More